SELECTED PUBLICATIONS
Farfara D, Sooliman M, Avrahami L, Royal TG, Amram S, Rozenstein-Tsalkovich L, Trudler D, Blanga-Kanfi S, Eldar-Finkelman H, Pahnke J, Rosenmann H, Frenkel D. Physiological expression of mutated TAU impaired astrocyte activity and exacerbates β-amyloid pathology in 5xFAD mice. J Neuroinflammation. 2023 Jul 26;20(1):174.
Chen W, Huang Q, Lazdon EK, Gomes A, Wong M, Stephens E, Royal TG, Frenkel D, Cai W, Kahn CR. Loss of insulin signaling in astrocytes exacerbates Alzheimer-like phenotypes in a 5xFAD mouse model. Proc Natl Acad Sci U S A. 2023 May 23;120(21)
Fursht, O., Liran, M., Nash, Y., Medala, V. K., Ini, D., Royal, T. G., Goldsmith, G., Nahary, L., Benhar, I., & Frenkel, D. (2022). Antibody-Mediated Inhibition of Insulin-Degrading Enzyme Improves Insulin Activity in a Diabetic Mouse Model. Frontiers in immunology, 13, 835774.
Sade Yazdi D, Laor Bar-Yosef D, Adsi H, Kreiser T, Sigal S, Bera S, Zaguri D, Shaham-Niv S, Oluwatoba DS, Levy D, Gartner M, Do TD, Frenkel D, Gazit E. (2021). Homocysteine fibrillar assemblies display crosstalk with Alzheimer's disease β-amyloid polypeptide. Proc Natl Acad Sci U S A. 118(24): e2017575118. 2.
Nash Y, Ganoth A, Borenstein-Auerbach N, Levy-Barazany H, Goldsmith G, Kopelevich A, Pozyuchenko K, Sakhneny L, Lazdon E, Blanga-Kanfi S, Alhadeff R, Benromano T, Landsman L, Tsfadia Y, Frenkel D. (2021). From virus to diabetestherapy: Characterization of a specific insulin-degrading enzyme inhibitor fordiabetes treatment. FASEB. 35(5): 213374. 3. 23.
Sofer Y, Nash Y, Osher E, Fursht O, Goldsmith G, Nahary L, Shaklai S, Tordjman KM, Serebro M, Touati EB, Yacobi Bach M, Marcus Y, Tal B, Sack J, Shefer G, Margaliot M, Landis N, Goldiner I, Abu Ahmad W, Stern N, Benhar I, Frenkel D. (2021). Insulin-degrading enzyme higher in subjects with metabolic syndrome.Endocrine. 71(2): 357-364. 4.
Stolero N, Frenkel D. (2021). The dialog between neurons and microglia in Alzheimer's disease: The neurotransmitters view.J Neurochem.158(6): 1412-1424.
Trudler D, Levy-Barazany H, Nash Y, Samuel L, Sharon R, Frenkel D. Alpha-synuclein deficiency increases CD4+ T-cells pro-inflammatory profile in a Nurr1-dependent manner. J Neurochem. 2020 Jan;152(1):61-71.
Pozyuchenko K, Shouchane-Blum K, Brody J, Lazdon E, Yassur I, Nisgav Y, Frenkel D, Stiebel-Kalish H. Investigating animal models of optic neuropathy: An accurate method for optic nerve and chiasm dissection in mice. J Neurosci Methods. 2020 Feb 1;331:
Shapira R, Solomon B, Efrati S, Frenkel D, Ashery U. Hyperbaric oxygen therapy ameliorates pathophysiology of 3xTg-AD mouse model by attenuating neuroinflammation. Neurobiol Aging. 2018 Feb;62:105-119.
Nash Y, Schmukler E, Trudler D, Pinkas-Kramarski R, Frenkel D. DJ-1 Deficiency Impairs Autophagy and Reduces Alpha-synuclein Phagocytosis by Microglia. J Neurochem. 2017 Sep 16.
Liu W, Rabinovich A, Nash Y, Frenkel D, Wang Y, Youdim MBH, Weinreb O. Anti-inflammatory and protective effects of MT-031, a novel multitarget MAO-A and AChE/BuChE inhibitor in a scopolamine mouse model and inflammatory cells. Neuropharmacology. 2017 Feb;113(Pt A):445-456.
Iram T, Trudler D, Kain D, Kanner S, Galron R, Vassar R, Barzilai A, Blinder P, Fishelson Z, Frenkel D. Astrocytes from old Alzheimer's disease mice are impaired in Aβ uptake and in neuroprotection. Neurobiol Dis. 2016 Dec;96:84-94.
Iram T., Byrne MH, Coleman UA, Kingery ND, Ramirez-Ortiz Z, Means TK, Frenkel D, El Khoury J. megf10 is a receptor for c1q and mediates clearance of apoptotic cells by astrocytes. Journal of Neuroscience
Simonovitch S., Schmukler E., Bespalkoa A., Iram T., Frenkel D., Holtzman DM, Masliah E., Michaelson DM, Pinkas-Kramarski R, Impaired Autophagy in APOE4 Astrocytes, 2016, 51(3) J of Alzheimer’s disease
Invited Commentary: Frenkel D. A new TRAIL in Alzheimer's disease therapy. Brain. 2015;138(Pt 1):8-10.
Holmgren S, Hjorth E, Schultzberg M, Lärksäter M, Frenkel D, Tysen-Bäckström AC, Aarsland D, Freund-Levi Y. Neuropsychiatric symptoms in dementia-a role for neuroinflammation? Brain Res Bull. 2014;108:88-93.
Farfara D, Tuby H, Trudler D, Doron-Mandel E, Maltz L, Vassar RJ, Frenkel D, Oron U. Low-level laser therapy ameliorates disease progression in a mouse model of Alzheimer's disease. J Mol Neurosci. 2015;55(2):430-6.
Bar-Shir A, Avram L, Yariv-Shoushan S, Anaby D, Cohen S, Segev-Amzaleg N, Frenkel D, Sadan O, Offen D, Cohen Y. Alginate-coated magnetic nanoparticles for noninvasive MRI of extracellular calcium. NMR Biomed. 2014 Jul;27(7):774-83.
Lotan D, Benhar I, Alvarez K, Mascaro-Blanco A, Brimberg L, Frenkel D, Cunningham MW, Joel D. Behavioral and neural effects of intra-striatal infusion of anti-streptococcal antibodies in rats. Brain Behav Immun. 2014;38:249-62.
Levy Barazany H, Barazany D, Puckett L, Blanga-Kanfi S, Borenstein-Auerbach N, Yang K, Peron JP, Weiner HL, Frenkel D. Brain MRI of nasal MOG therapeutic effect in relapsing-progressive EAE. Exp Neurol. 2014;255:63-70.
Trudler D, Weinreb O, Mandel SA, Youdim MB, Frenkel D. DJ-1 deficiency triggers microglia sensitivity to dopamine toward a pro-inflammatory phenotype that is attenuated by Rasagiline. J Neurochem. 2014;129(3):434-47.
Frenkel D, Wilkinson K, Zhao L, Hickman SE, Means TK, Puckett L, Farfara D, Kingery ND, Weiner HL, El Khoury J. Scara1 deficiency impairs clearance of soluble amyloid-β by mononuclear phagocytes and accelerates Alzheimer's-like disease progression. Nat Commun. 2013;4:2030.
Segev-Amzaleg N, Trudler D, Frenkel D. Preconditioning to mild oxidative stress mediates astroglial neuroprotection in an IL-10-dependent manner. Brain Behav Immun. 2013 30:176-85.
Lifshitz V, Benromano T, Weiss R, Blanga-Kanfi S, Frenkel D. Insulin-degrading enzyme deficiency accelerates cerebrovascular amyloidosis in an animal model. Brain Behav Immun. 2013 May;30:143-9 .
Avrahami L, Farfara D, Shaham-Kol M, Vassar R, Frenkel D, Eldar-Finkelman H Inhibition of glycogen synthase kinase-3 ameliorates β-amyloid pathology and restores lysosomal acidification and mammalian target of rapamycin activity in the Alzheimer disease mouse model: in vivo and in vitro studies .J Biol Chem. 2013 Jan 11;288(2):1295-306.
Lifshitz V, Weiss R, Levy H, Frenkel D. Scavenger receptor A deficiency accelerates cerebrovascular amyloidosis in an animal model. J Mol Neurosci. 2013 ;50(1):198-203.
Kirshner M, Galron R, Frenkel D, Mandelbaum G, Shiloh Y, Wang ZQ, Barzilai A. Malfunctioning DNA damage response (DDR) leads to the degeneration of the nigrostriatal pathway in mouse brain. J Mol Neurosci. 2012 Mar;46(3):554-68.
Adler-Abramovich L, Vaks L, Carny O, Trudler D, Magno A, Caflisch A, Frenkel D, Gazit E. Phenylalanine assembly into toxic fibrils suggests amyloid etiology in phenylketonuria. Nat Chem Biol. 2012 8(8):701-6.
Levy-Barazany H, Frenkel D. Expression of scavenger receptor A on antigen-presenting cells is important for CD4+ T-cells proliferation in EAE mouse model. J Neuroinflammation. 2012 7;9:120.
Scherzer-Attali R, Farfara D, Cooper I, Levin A, Ben-Romano T, Trudler D, Vientrov M, Shaltiel-Karyo R, Shalev DE, Segev-Amzaleg N, Gazit E, Segal D, Frenkel D. Naphthoquinone-tryptophan reduces neurotoxic Aβ*56 levels and improves cognition in Alzheimer's disease animal model. Neurobiol Dis. 2012 Jun;46(3):663-72
Raz-Prag D., Galron R., Segev-Amzaleg N., Barzilai A., Shiloh Y., and Frenkel D. A role for vascular deficiency in retinal pathology in a mouse model of ataxia-telangiectasia, The American Journal of Pathology 2011 179(3):1533-41.
Galron R., Gruber R. Kirshner M. Ziv N. Wang ZO. Shiloh Y. Barzilai A., and Frenkel D. Astrocyte Dysfunction associated with cerebellar attrition in Nijmegen Breakage Syndrome Animal Model, JMN 2011 45(2):202-11.
Frydman-Marom A., Levin A., Farfara D., Benromano T., Scherzer-Attali1 R., Vassar R., Segal D., Gazit E., Frenkel D., and Ovadia M., Orally administrated cinnamon extract reduces beta-amyloid oligomerization and corrects cognitive impairment in Alzheimer's disease animal models PloS One, 2011. 6(1):e16564
Lifshitz V., Benromano T., Kfir E., Blumenfeld-Katzir T. a, Tempel-Brami C. Assaf Y., Xia W., Wyss-Coray T., Weiner HL, and Frenkel D. Immunotherapy of cereberovascular amloidosis in a transgenic mouse model, Neurobiology of aging , 33(2):432.e1-432.e13.
Weiss R. Lifshitz V, Frenkel D. TGF-β1 affects endothelial cell interaction with macrophage and Th1 T-cells leading to the development of cerebrovascular amyloidosis Brain Behav Immun. 2011 25(5):1017-24
Goldfarb Y, Levi B, Sorski L, Frenkel D, Ben-Eliyahu S CpG-C immunotherapeutic efficacy is jeopardized by ongoing exposure to stress: Potential implications for clinical use Brain Behav Immun. 2011 25(1):67-76.
Farfara D., Trudler D., Amzaleg-Segev N., Galron R., Stein R., Frenkel D. Gamma-secretase component presenilin mediates microglia beta amyloid clearance. Ann Neurology, 2011, 69(1):170-80. doi: 10.1002/ana.22191.
Levy H, Assaf Y, Frenkel D. Characterization of brain lesions in a mouse model of progressive multiple sclerosis. Exp Neurol. 2010 226(1):148-58.